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KMID : 0545120190290081248
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Journal of Microbiology and Biotechnology
2019 Volume.29 No. 8 p.1248 ~ p.1254
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Heat-Killed Lactobacillus plantarum KCTC 13314BP Enhances Phagocytic Activity and Immunomodulatory Effects Via Activation of MAPK and STAT3 Pathways
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Jeong Min-Ju
Kim Jae-Hwan
Yang Hee
Kang Shin-Dal
Song Seong-Bong
Lee Deuk-Buhm
Lee Ji-Su
Park Jung-Han-Yoon
Byun Sang-Uine
Lee Ki-Won
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Abstract
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Identification of novel probiotic strains is of great interest in the field of functional foods. Specific strains of heat-killed bacteria have been reported to exert immunomodulatory effects. Herein, we investigated the immune-stimulatory function of heat-killed Lactobacillus plantarum KCTC 13314BP (LBP). Treatment with LBP significantly increased the production of TNF-α and IL-6 by macrophages. More importantly, LBP was able to enhance the phagocytic activity of macrophages against bacterial particles. Activation of p38, JNK, ERK, NF-κB, and STAT3 was involved in the immunomodulatory function of LBP. LBP treatment significantly increased production of TNF-α by bone marrow-derived macrophages and splenocytes, further confirming the immunostimulatory effect of LBP in primary immune cells. Interestingly, the immunomodulatory effects of LBP were much stronger than those of Lactobacillus rhamnosus GG, a well-known probiotic strain. These results indicate that LBP can be a promising immune-enhancing functional food agent.
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KEYWORD
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Lactobacillus plantarum, immunomodulatory effect, phagocytosis, macrophages
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